Oxime genotoxicity
WebNov 27, 2024 · Here we report a universal base excision reporter (UBER) fluorescence probe design that implements an unprecedentedly rapid oxime reaction (>150 M –1 s –1) with high specificity for the abasic (AP) site of DNA. The molecular rotor design achieves a robust >250–500-fold increase in fluorescence upon reaction with AP sites in DNA. WebSeveral recent examples of reduction of oximes and oxime ethers to primary amines are listed in Table 11.Several combinations of NaBH 4 with transition metal salts were used …
Oxime genotoxicity
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WebEvaluation of the cyto/genotoxicity profile of oxime K048 using human peripheral blood lymphocytes: an introductory study. @article{LuciVrdoljak2014EvaluationOT, title={Evaluation of the cyto/genotoxicity profile of oxime K048 using human peripheral blood lymphocytes: an introductory study.}, author={Ana Luci{\'c} Vrdoljak and Suzana … WebFeb 1, 1988 · To aid in the selection of chemical candidates for in vivo tests, the mutagenicity of 6 oxime compounds was evaluated in the Salmonella plate incorporation …
WebNov 5, 2024 · The 9-anthraldehyde oxime (CAS 34810-13-4) has been tested for genotoxicity directly from its molecular structure and it was found an IMAX + S9 = 1.22; IMAX − S9 = …
WebMar 1, 2014 · Organophosphate poisoning, resulting from exposure to organophosphate nerve agents, is caused by the inhibition of acetyl cholinesterase (AChE) via a mechanism of phosphorylation of the serine hydroxyl residue, leading to the accumulation of acetylcholine (ACh) in the body. This causes disturbances across the cholinergic synapses. WebFeb 1, 1988 · Mutation Research, 204 (1988) 149-162 Elsevier MTR 01241 Genotoxicity of 6 oxime compounds in the Salmonella/ mammalian-microsome assay and mouse lymphoma TK+/- assay A.M. Rogers-Back', T.E. Lawlor ', T.P. Cameron 2 and V.C. Dunkel 3 I Microbiological Associates, Bethesda, MD 20816, z National Cancer Institute, Bethesda, …
WebJun 27, 2013 · This study investigates the effects of oxime K048 (730, 200, and 7.3nM) on the viability and chromosome stability of human peripheral blood lymphocytes (PBLs) after a 30min exposure in vitro....
WebDec 9, 2011 · The cyto-/genotoxic profiles of oximes have not yet been extensively studied. Svobodova et al. [59] recently studied the cytotoxicity and genotoxicity of selected antidotes (obidoxime,... ulta beauty summerville scWebJun 22, 2024 · The formation of oximes and hydrazones is employed in numerous scientific fields as a simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as diverse as polymer chemistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical biology. ulta beauty tarte eyeshadowWebSep 15, 2024 · We also examined if 6BIO could protect cells from the genotoxic impact of oxidants or genotoxic agents. We initially assessed the phosphorylation of H 2 A.X (termed γΗ 2 Α.Χ) on Ser 139 ; a ... ulta beauty teeth whiteningWebOct 12, 2013 · Taken together, the present evaluation of the K048 oxime has revealed that the compound applied at 25% of its LD 50 did not significantly affect ChE activity and lipid peroxidation and that it did not cause significant changes in the SOD activity in plasma. The cyto-/genotoxicity profile of the oxime applied at the tested dose was also acceptable. ulta beauty tacomaWebMar 1, 2014 · To evaluate the sensitivity of the SOS-Chromo-spottest towards genotoxic compounds 5 reference chemicals (4-nitroquinoline-1-oxide (4-NQO), methylmethansulfonate (MMS),... ulta beauty tracking orderWebNov 1, 2013 · K048 is a member of K-oximes, a new oxime class that has recently been confirmed effective against poisoning by the nerve agent tabun and several pesticides. The toxicity profile of the K048... thong man austin txWebOct 12, 2013 · In Vivo Evaluation of Cholinesterase Activity, Oxidative Stress Markers, Cyto‐ and Genotoxicity of K048 Oxime – a Promising Antidote against Organophosphate Poisoning Suzana Žunec. Institute for Medical Research and Occupational Health, Zagreb, Croatia. ... The obtained results are promising for further evaluations of the K048 oxime, … ulta beauty tea tree