Eif4a3 location
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in WebEukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay …
Eif4a3 location
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WebNov 23, 2024 · Our findings indicate that eIF4A3-induced circMMP9 is an important underlying mechanism in GBM cell proliferation, invasion and metastasis through modulation of the miR-124 signaling pathway, which could provide pivotal potential therapeutic targets for the treatment of GBM. ... In addition, we explored the location of circMMP9 in U87 … WebEIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway. The exon junction complex core factor eIF4A3 is a key …
WebeIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses. Viral infection activates the type I interferons (IFNs) and cellular antiviral responses. … WebOct 2, 2014 · One attractive hypothesis is that alternative splicing of 5' UTR sequences facilitates translation of spliced mRNAs through recruitment of eIF4A3. In support of this, evidence suggests that the role of eIF4A3 in translation includes the ATP-dependent rearrangement of protein-protein or protein-mRNA complexes since this nuclear isoform …
WebAug 4, 2024 · EIF4A3 localizes in transcriptionally active nucleoli and safeguards the nucleolar structure. (A) Representative IF images of eIF4A3 localization in U2OS cells … WebB & C. Relative protein level of FOXO1, beclin1, eIF4A3, and LC3B in ox-LDL treated HUVECs. One-way ANOVA. Compared with 0 h, ***p < 0.001. n ≥ 6. D -F. Overexpression of hsa_circ_0030042 in HUVECs.
WebDec 13, 2024 · EIF4A3-induced circBRWD3 promotes tumorigenesis of breast cancer through miR-142-3p_miR-142-5p/RAC1/PAK1 signaling. Meng X, Li W, Meng Z, Li YMeng X, et al. BMC Cancer, 2024 Nov 28. PMID 36443711; Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation …
WebeIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC 50 =0.26 μM; K d =0.043 μM), which binds to a non-ATP binding site of eIF4A3 and … firefly utility scale solar energy facilityWebClinVar archives and aggregates information about relationships among variation and human health. ethan hatfield lex kyWebJun 9, 2024 · EIF4A3 has been revealed to play a critical role in RNA splicing, location, and degradation . As an important RNA-binding protein, EIF4A3 was revealed to be involved in RNA exon splicing by forming exon junction complexes [ 30 ]. firefly v1g laser flashlightWebMay 3, 2024 · The RNA helicase EIF4A3 regulates the exon junction complex and nonsense-mediated mRNA decay functions in RNA transcript processing. However, a transcriptome-wide network definition of these functions has been lacking, in part due to the lack of suitable pharmacological inhibitors. ethan hatch baseballWebAug 2, 2024 · Eukaryotic initiation factor 4A3 (EIF4A3) is a member of the DEAD-box RNA helicase family and regarded as one of the special components of the exon junction complex (EJC). EIF4A3 is involved in various RNA metabolic processes such as nonsense-mediated RNA decay (NMD) and RNA splicing ( 20, 21 ). firefly v5WebMar 21, 2024 · EIF4A3 (Eukaryotic Translation Initiation Factor 4A3) is a Protein Coding gene. Diseases associated with EIF4A3 include Robin Sequence With Cleft Mandible … ethan hastertWebChr Location 17q25.3; chr17:80135214-80147183 (-) GRCh38.p7. Alliance of Genome Resources. Eif4a3 ... J:242590 Miller EE, et al., EIF4A3 deficient human iPSCs and … firefly v2 replacement charger